PTPN22 1858C>T polymorphism distribution in Europe and association with rheumatoid arthritis: case-control study and meta-analysis

Articolo

Data di Pubblicazione:

2011

Citazione:

Totaro, M., Tolusso, B., Napolioni, V., Faustini, F., Canestri, S., Mannocci, A., Gremese, E., Bosello, S., Alivernini, S., Ferraccioli, G., PTPN22 1858C>T polymorphism distribution in Europe and association with rheumatoid arthritis: case-control study and meta-analysis, <>, 2011; 6 (9): e24292-e24292. [doi:10.1371/journal.pone.0024292] [http://hdl.handle.net/10807/3409]

Abstract:

The PTPN22 rs2476601 polymorphism is associated with rheumatoid arthritis (RA); nonetheless, the association is weaker or absent in some southern European populations. The aim of the study was to evaluate the association between the PTPN22 rs2476601 polymorphism and RA in Italian subjects and to compare our results with those of other European countries, carrying out a meta-analysis of European data.

Tipologia CRIS:

Articolo in rivista, Nota a sentenza

Keywords:

Polymorphism, Single Nucleotide; Adult; Aged; Arthritis, Rheumatoid; Case-Control Studies; Europe; Gene Frequency; Genetic Predisposition to Disease; Genotype; Geography; Greece; Humans; Italy; Middle Aged; Mutation Rate; Protein Tyrosine Phosphatase, Non-Receptor Type 22; Spain; Tunisia; Turkey

Elenco autori: