Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes

Articolo

Data di Pubblicazione:

2015

Citazione:

Paneni, F., Costantino, S., Castello, L., Battista, R., Capretti, G., Chiandotto, S., D'Amario, D., Scavone, G., Villano, A., Rustighi, A., Crea, F., Pitocco, D., Lanza, G. A., Volpe, M., Del Sal, G., Lüscher, T., Cosentino, F., Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes, <>, 2015; 36 (13): 817-828. [doi:10.1093/eurheartj/ehu179] [http://hdl.handle.net/10807/69144]

Abstract:

Diabetes is a major driver of cardiovascular disease, but the underlying mechanisms remain elusive. Prolyl-isomerase Pin1 recognizes specific peptide bonds and modulates function of proteins altering cellular homoeostasis. The present study investigates Pin1 role in diabetes-induced vascular disease.

Tipologia CRIS:

Articolo in rivista, Nota a sentenza

Keywords:

Diabetes mellitus; Endothelial function; Inflammation; Oxidative stress

Elenco autori: