Selection of appropriate end-points (pCR vs 2yDFS) for tailoring treatments with prediction models in locally advanced rectal cancer
Academic Article
Publication Date:
2015
Short description:
Valentini, V., Van Stiphout, R., Lammering, G., Gambacorta, M. A., Barba, M., Bebenek, M., Bonnetain, F., Bosset, J., Bujko, K., Cionini, L., Gerard, J., Rödel, C., Sainato, A., Sauer, R., Minsky, B., Collette, L., Lambin, P., Selection of appropriate end-points (pCR vs 2yDFS) for tailoring treatments with prediction models in locally advanced rectal cancer, <>, 2015; 114 (3): 302-309. [doi:10.1016/j.radonc.2015.02.001] [http://hdl.handle.net/10807/66966]
abstract:
Personalized treatments based on predictions for patient outcome require early characterization of a rectal cancer patient's sensitivity to treatment. This study has two aims: (1) identify the main patterns of recurrence and response to the treatments (2) evaluate pathologic complete response (pCR) and two-year disease-free survival (2yDFS) for overall survival (OS) and their potential to be relevant intermediate endpoints to predict.
Iris type:
Articolo in rivista, Nota a sentenza
Keywords:
Disease-free survival; Pathological complete response; Personalized treatment; Prediction models; Rectal cancer; Risk ratio
List of contributors:
Valentini, Vincenzo; Van Stiphout, Rg; Lammering, G; Gambacorta, Maria Antonietta; Barba, Mc; Bebenek, M; Bonnetain, F; Bosset, Jf; Bujko, K; Cionini, L; Gerard, Jp; Rödel, C; Sainato, A; Sauer, R; Minsky, Bd; Collette, L; Lambin, P.
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