Skip to Main Content (Press Enter)

Logo UNICATT
  • ×
  • Home
  • Degrees
  • Courses
  • People
  • Outputs
  • Projects
  • Expertise & Skills

UNI-FIND
Logo UNICATT

|

UNI-FIND

unicatt.it
  • ×
  • Home
  • Degrees
  • Courses
  • People
  • Outputs
  • Projects
  • Expertise & Skills
  1. Outputs

Mapping the human genetic architecture of COVID-19

Academic Article
Publication Date:
2021
Short description:
Niemi,, And Karjalainen, M. E. K., And Daly, J., And Ganna, M., And Mehtonen, A., And Cordioli, J., And Kaunisto, M., And Pigazzini, M., And Donner, S., And Kivinen, K., And Palotie, K., And Daly, A., And Liao, M. J., And Kanai, R. G., And Veerapen, M., And Minica, K., And Trankiem, C., And Balaconis, A., And Nguyen, M. K., And Solomonson, H., And Francioli, M., And Wang, L., And Green, Q., And Bryant, R. C., And Finucane, S., And Martin, H., And Zhou, A. R., And Nkambule, W., And Karczewski, L., And Atkinson, K. J., And Tsuo, E. G., And Baya, K., And Turley, N., And Gupta, P., And Walters, R., And Palmer, R. K., And Sarma, D. S., And Cheng, G., And Lu, N., And Churchhouse, W., And Goldstein, C., I,, And King, J., And Seed, D., And Neale, C., And Satterstrom, B. M., Kyle And Pathak, F., And Wendt, G. A., And Polimanti, F. R., And Andrews, R., And Sloofman, S. J., And Sealfon, L., And Fernandez-Cadenas, S. C., And Schulte, I., And Protzer, E. C., And Striano, U., And Coviello, P., And Zara, D. A., And Salpietro, F., Iacomino, V., And Scudieri, M., And Bocciardi, P., And Minetti, R., And Vari, C., Stella And Madia, M., And Marouli, F., And Kanoni, E., And Moutsianas, S., And Karim, L., Anisul And Ghoussaini, M., And Schwartzentruber, M., And Dunham, J., And Savage, I., And Posthuma, J., And Tissink, D., And Uffelmann, E., And Butler-Laporte, E., And Richards, G., Brent And Nakanishi, J., And Morrison, T., And Forgetta, D. R., And Ghosh, V., And Laurent, B., And Henry, L., And Abdullah, D., And Adeleye, T., And Mamlouk, O., And Kimchi, N., And Afrasiabi, N., And Rezk, Z., And Vulesevic, N., And Bouab, B., And Guzman, M., And Petitjean, C., And Tselios, L., And Xue, C., And Afilalo, X., And Adra, J., And Kim, D., And Okada, H., And Byun, Y., And Han, J., And Uddin, Y., Jashim And Smith, M., Davey And Willer, G., And Buxbaum, C. J., And Sloofman, J. D., And Collins, L. G., And Levy, B. L., And Underwood, T., And Britvan, S. J., And Keller, B., And Tang, K., And Peruggia, L., And Hiester, M., And Niblo, L. L., And Aksentijevich, K., And Labkowsky, A., And Karp, A., And Zlatopolsky, A., And Arora, M., And Raychaudhuri, J., And Mercader, S., And Cusick, J., And Pasaniuc, C., And Julienne, B., And Aschard, H., And Shi, H., And Yengo, H., And Chwialkowska, L., And Francescatto, K., And Davis, M., And Kerchberger, L., Eric And Lee, V., And Priest, S., And Vadgama, J., And Tanigawa, N., And Renieri, Y., And Sankaran, A., And Van Heel, V. G., And De Salazar, D., And Van Heel, A., And Hunt, D. A., And Trivedi, K. A., And Deelen, B., And Franke, P., And Claringbould, L., And Lopera, A., And Warmerdam, E., And Van Blokland, R., And Lanting, I., And Mooser, P., And Li, V., And Belisle, R., And Lepage, A., And Ragoussis, P., And Auld, J., And Lathrop, D., Mark And Biesecker, G., And Baillie, L., Kenneth And Clohisey, J., And Fourman, S., Head And Furniss, M., And Haley, J., And Law, C., And Millar, A., And Pairo-Castineira, J., And Parkinson, E., And Rawlik, N., And Russell, K., And Shih, C. D., And Tenesa, B., And Wang, A., And Zechner, B., And Law, M., And Hendry, A., And Armstrong, R., And Boz, R., And Brown, C., And Cullum, A., And Day, L., And Duncan, N., And Finernan, E., And Golightly, P., And Law, A., And Law, D., And Law, R., And Mal, S., And Mcmaster, H., And Meikle, E., And Oosthuyzen, J., And Paterson, W., And Stenhouse, T., And Swets, A., And Szoor-Mcelhinney, M., And Taneski, H., And Wackett, F., And Ward, T., And Weaver, M., And Coyle, J., And Gallagher, J., And Lidstone-Scott, B., And Hamilton, R., And Griffiths, D., And Keating, F., And Walsh, S., And Bretherick, T., And Grimes, A. D., And Hayward, G., And Klaric, C., And Meynert, L., And Ponting, A. M., And Richmond, C. P., And Vitart, A., And Wilson, V., And Mari, J. F., And Lista, F., And Perticaroli, M., And Fallerini, V., And Daga, C., And Baldassarri, S., And Fava, M., And Frullanti, F., And Valentino, E., And Doddato, F., And Giliberti, G., And Bruttini, A., And Croci, M
abstract:
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-19(1,2), host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases(3-7). They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease.
Iris type:
Articolo in rivista, Nota a sentenza
Keywords:
covid-19
List of contributors:
Niemi, ; and Karjalainen, Mari E. K.; and Daly, Juha; and Ganna, Mark; and Mehtonen, Andrea; and Cordioli, Juha; and Kaunisto, Mattia; and Pigazzini, Mari; and Donner, Sara; and Kivinen, Kati; and Palotie, Katja; and Daly, Aarno; and Liao, Mark J.; and Kanai, Rachel G.; and Veerapen, Masahiro; and Minica, Kumar; and Trankiem, Camelia; and Balaconis, Amy; and Nguyen, Mary K.; and Solomonson, Huy; and Francioli, Matthew; and Wang, Laurent; and Green, Qingbo; and Bryant, Robert C.; and Finucane, Sam; and Martin, Hilary; and Zhou, Alicia R.; and Nkambule, Wei; and Karczewski, Lindokuhle; and Atkinson, Konrad J.; and Tsuo, Elizabeth G.; and Baya, Kristin; and Turley, Nikolas; and Gupta, Patrick; and Walters, Rahul; and Palmer, Raymond K.; and Sarma, Duncan S.; and Cheng, Gopal; and Lu, Nathan; and Churchhouse, Wenhan; and Goldstein, Claire; I, ; and King, Jacqueline; and Seed, Daniel; and Neale, Cotton; and Satterstrom, Benjamin M.; Kyle and Pathak, F.; and Wendt, Gita A.; and Polimanti, Frank R.; and Andrews, Renato; and Sloofman, Shea J.; and Sealfon, Laura; and Fernandez-Cadenas, Stuart C.; and Schulte, Israel; and Protzer, Eva C.; and Striano, Ulrike; and Coviello, Pasquale; and Zara, Domenico A.; and Salpietro, Federico; Iacomino, Vincenzo; and Scudieri, Michele; and Bocciardi, Paolo; and Minetti, Renata; and Vari, Carlo; Stella and Madia, Maria; and Marouli, Francesca; and Kanoni, Eirini; and Moutsianas, Stavroula; and Karim, Loukas; Anisul and Ghoussaini, Mohd; and Schwartzentruber, Maya; and Dunham, Jeremy; and Savage, Ian; and Posthuma, Jeanne; and Tissink, Danielle; and Uffelmann, Elleke; and Butler-Laporte, Emil; and Richards, Guillaume; Brent and Nakanishi, J.; and Morrison, Tomoko; and Forgetta, David R.; and Ghosh, Vincenzo; and Laurent, Biswarup; and Henry, Laetitia; and Abdullah, Danielle; and Adeleye, Tala; and Mamlouk, Olumide; and Kimchi, Noor; and Afrasiabi, Nofar; and Rezk, Zaman; and Vulesevic, Nardin; and Bouab, Branka; and Guzman, Meriem; and Petitjean, Charlotte; and Tselios, Louis; and Xue, Chris; and Afilalo, Xiaoqing; and Adra, Jonathan; and Kim, Darin; and Okada, Han-Na; and Byun, Yukinori; and Han, Jinyoung; and Uddin, Younghun; Jashim and Smith, Mohammed; Davey and Willer, George; and Buxbaum, Cristen J.; and Sloofman, Joseph D.; and Collins, Laura G.; and Levy, Brett L.; and Underwood, Tess; and Britvan, Slayton J.; and Keller, Bari; and Tang, Katherine; and Peruggia, Lara; and Hiester, Michael; and Niblo, Liam L.; and Aksentijevich, Kristi; and Labkowsky, Alexandra; and Karp, Alexander; and Zlatopolsky, Avromie; and Arora, Menachem; and Raychaudhuri, Jatin; and Mercader, Soumya; and Cusick, Josep; and Pasaniuc, Caroline; and Julienne, Bogdan; and Aschard, Hanna; and Shi, Hugues; and Yengo, Huwenbo; and Chwialkowska, Loic; and Francescatto, Karolina; and Davis, Margherita; and Kerchberger, Lea; Eric and Lee, V.; and Priest, Sulggi; and Vadgama, James; and Tanigawa, Nirmal; and Renieri, Yosuke; and Sankaran, Alessandra; and van Heel, Vijay G.; and de Salazar, David; and van Heel, Adolfo; and Hunt, David A.; and Trivedi, Karen A.; and Deelen, Bhavi; and Franke, Patrick; and Claringbould, Lude; and Lopera, Annique; and Warmerdam, Esteban; and van Blokland, Robert; and Lanting, Irene; and Mooser, Pauline; and Li, Vincent; and Belisle, Rui; and Lepage, Alexandre; and Ragoussis, Pierre; and Auld, Jiannis; and Lathrop, Daniel; Mark and Biesecker, G.; and Baillie, Les; Kenneth and Clohisey, J.; and Fourman, Sara; Head and Furniss, Max; and Haley, James; and Law, Chris; and Millar, Andy; and Pairo-Castineira, Jonathan; and Parkinson, Erola; and Rawlik, Nicholas; and Russell, Konrad; and Shih, Clark D.; and Tenesa, Barbara; and Wang, Albert; and Zechner, Bo; and Law, Marie; and Hendry, Andrew; and Armstrong, Ross; and Boz, Ruth; and Brown, Ceilia; and Cullum, Adam; and Day, Louise; and Duncan, Nicky; and Finernan, Esther; and Golightly, Paul; and Law, Ailsa; and Law, Dawn; and Law, Rachel; and Mal, Sarah; and
Handle:
https://publicatt.unicatt.it/handle/10807/234174
Published in:
NATURE
Journal
  • Research Fields

Research Fields

Concepts (2)


LS1_2 - Biochemistry - (2022)

Settore BIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA
  • Use of cookies

Powered by VIVO | Designed by Cineca | 26.4.5.0